Cotabato City National High School-main Campus was formally established in 1924 with its former name, Cotabato City High School. It was originally located at Cotabato Central Pilot School, in the heart of the city. After World War II, it was transferred at Sinsuat Avenue along the National Highway in an eight-hectare land donated by the prominent Sero family. It’s name was changed to Cotabato Provincial High School after a while because it was operated by the empire province of Cotabato
In 1976, under the sponsorship of former Commisioner Simeon Datumanong and City Mayor Johny Ty,it was placed under the management of the City of Cotabato. Due to financial constraint, it was returned back under the control of the national government on July 20,1977. From Cotabato City High School, it was later changed to Cotabato City National High School.
